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Pyrroloindole analogues of ellipticine. The synthesis and DNA intercalative properties of 5,10-dihyhdro-5,10,dimethyl-2,5,10-triazadibenzo[a,e]pentalene

✍ Scribed by R.Alan Jones; Joachim Pastor; Jorge Siro; Tevita N. Voro

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
472 KB
Volume
53
Category
Article
ISSN
0040-4020

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✦ Synopsis

The title compound, 2, and its 2-methyl salt, 8, have been synthesised

The pKa of the conjugate acid of 2 is similar to those of ellipticine and its 9-hydroxy and 9methoxy derivatives, and intercalation studies with DNA show that 2 and 8 have association constants comparable with the anti-cancer ellipticine derivatives.

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