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Pyrrolizidine synthesis by intramolecular cyclization of a substituted azacyclooctane-4,5-oxide

✍ Scribed by Richard S. Glass; Donald R. Deardorff; Lawrence H. Gains

Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
216 KB
Volume
19
Category
Article
ISSN
0040-4039

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✦ Synopsis

Pyrrolizidine alkaloids have been isolated from a variety of plant families.' In addition they have been found in several species of butterflies and moths2 and in a millipede.3 The pharmacology of these alkaloids has been studied extensively 134 and dangers to human health recognized. 4b,5 Recently, a number of synthetic results to the pyrrolizidine ring system (l-azabicyclo [3.3.0] octane) have been published.6 A transannular route to this ring system has been communicated' and also used8 in a synthesis of hemiloline la as described in the accompanying paper.

In view of these results our related independent work is presented here.

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