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Pyrrolizidine Alkaloids and Bisabolane Sesquiterpenes from the Roots of Ligularia cymbulifera

✍ Scribed by Chun-Mei Liu; He-Xiang Wang; Shi-Lei Wei; Kun Gao

Publisher
John Wiley and Sons
Year
2008
Tongue
German
Weight
217 KB
Volume
91
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The new pyrrolizidine alkaloid glycoside 1, and the three new highly oxygenated bisabolane sesquiterpenes 4–6, together with the two known pyrrolizidine alkaloids 2 and 3, were isolated from the roots of Ligularia cymbulifera (W. W. Smith) Hand.‐Mazz. Their structures were established on the basis of spectroscopic analysis, especially 1D‐ and 2D‐NMR data. The cytotoxic activities of compounds 1, 2, and 4–6 were evaluated against hepatoma (BEL‐7402), human leukemia (HL‐60), human ovarian carcinoma (HO‐8910), and nasopharyngeal carcinoma (KB) cell lines (Tables 1–3). Compound 6 showed weak cell‐growth inhibition of BEL‐7402 cell.

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