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Pyrrole, furan, and thiophene oxamates as potential antiallergy agents

✍ Scribed by Fredda H. Briggs; William T. Pelletier; C. Dewitt Blanton Jr.


Book ID
102405915
Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
346 KB
Volume
67
Category
Article
ISSN
0022-3549

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✦ Synopsis


Nine heterocyclic oxamic acid derivatives were synthesized and tested in the rat passive cutaneous anaphylactic assay as potential antiallergy agents. Some compounds also were tested for their effects on cholesterol-lipoprotein levels and for diuretic, antidiabetic, and antifertility activities in rats.


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Sulfamic acid as efficient and reusable
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## Abstract Sulfamic acid has been utilized for the first time as an efficient and reusable catalytic system for the synthesis of heteroaromatics such as pyrrole, furan, and thiophene derivatives from 1,4‐diketones. This new procedure offers significant improvements in the reaction rates and yields