Pyrrole-2-carbohydrazides as Ligands for Cu-Catalyzed Amination of Aryl Halides with Amines in Pure Water

✍ Scribed by Jianwei Xie; Xinhai Zhu; Manna Huang; Fei Meng; Weiwei Chen; Yiqian Wan

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 512 KB
• Volume: 2010
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.201000361

✦ Synopsis

Abstract

Pyrrole‐2‐carbohydrazides were synthesized and found to be novel and efficient ligands for the Cu‐catalyzed amination of aryl halides with amines in pure water with high yields. A variety of aryl bromides or iodides could be aminated, promoted by the CuI/N′‐phenyl‐1__H__‐pyrrole‐2‐carbohydrazide (L13) system, under microwave irradiation or conventional heating without the protection by an inert gas.