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Pyroglutamylated Amyloid-Beta Peptide Reverses Cross Beta-Sheets by a Prion-Like Mechanism

✍ Scribed by Matos, Jason O.; Goldblatt, Greg; Tatulian, Suren A.


Book ID
123521854
Publisher
Biophysical Society
Year
2014
Tongue
English
Weight
109 KB
Volume
106
Category
Article
ISSN
0006-3495

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## Abstract In this DFT study, a mechanism of the oxidation of methionine (Met) amino acid residue catalyzed by the metal (Cu^2+^, Zn^2+^, and Fe^3+^) bound amyloid beta (AΞ²) peptide has been proposed. Based on experimental information, two different mechanisms: (1) stepwise and (2) concerted mecha