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Mechanism of Hydrogen Peroxide Production by Copper-Bound Amyloid Beta Peptide: A Theoretical Study

โœ Scribed by Hewitt, Nadine; Rauk, Arvi


Book ID
118161540
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
428 KB
Volume
113
Category
Article
ISSN
0022-3654

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## Abstract In this DFT study, a mechanism of the oxidation of methionine (Met) amino acid residue catalyzed by the metal (Cu^2+^, Zn^2+^, and Fe^3+^) bound amyloid beta (Aฮฒ) peptide has been proposed. Based on experimental information, two different mechanisms: (1) stepwise and (2) concerted mecha