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Pyrimidine Nucleoside Depletion Sensitizes to the Mitochondrial Hepatotoxicity of the Reverse Transcriptase Inhibitor Stavudine

✍ Scribed by Bernhard Setzer; Dirk Lebrecht; Ulrich A. Walker


Book ID
117970744
Publisher
American Society for Investigative Pathology
Year
2008
Tongue
English
Weight
536 KB
Volume
172
Category
Article
ISSN
0002-9440

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Thymidine analogue reverse transcriptase
✍ Anne-GeneviΓ¨ve Marcelin; Constance Delaugerre; Marc Wirden; Pedro Viegas; Anne S πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 71 KB

During ZDV or d4T exposure, mutations at codons 41, 67, 70, 210, 215, and 219 can be selected and were named thymidine analogue mutations (TAMs). Some previous results suggested that different TAMs patterns could exist and that the kind of TAMs pattern could influence the virological response to som