During ZDV or d4T exposure, mutations at codons 41, 67, 70, 210, 215, and 219 can be selected and were named thymidine analogue mutations (TAMs). Some previous results suggested that different TAMs patterns could exist and that the kind of TAMs pattern could influence the virological response to som
β¦ LIBER β¦
Insights on Resistance to Reverse Transcriptase: The Different Patterns of Interaction of the Nucleoside Reverse Transcriptase Inhibitors in the Deoxyribonucleotide Triphosphate Binding Site Relative to the Normal Substrate
β Scribed by Carvalho, Alexandra T. P.; Fernandes, Pedro A.; Ramos, Maria J.
- Book ID
- 126329372
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 263 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0022-2623
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## Abstract It has been reported that a new pattern of mutations, E44D/A and/or V118I, in the reverse transcriptase (RT) gene of HIVβ1 confers a moderate level of resistance to lamivudine in the absence of the M184V mutation. The prevalence of this mutational pattern was studied in HIVβ1 isolates o
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