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PYRIMETHAMINE-INDUCED ALTERATIONS IN HUMAN LYMPHOCYTES IN VITRO Mechanisms and Reversal of the Effect

✍ Scribed by BYGBJERG, IB CHRISTIAN


Book ID
114822130
Publisher
Wiley (Blackwell Publishing)
Year
2009
Weight
453 KB
Volume
93C
Category
Article
ISSN
0108-0202

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In this study the clastogenic effect of pyrimethamine (Daraprim), a folic acid antagonist used for the treatment of toxoplasmosis and malaria on human chromosomes, was investigated. Pyrimethamine was added to in vitro lymphocyte cultures at six different concentrations: 0.05 (normal therapeutic dose