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Pyridostigmine bromide protection against acetylcholinesterase inhibition by pesticides

✍ Scribed by John D. Henderson; Gabriela Glucksman; Bryan Leong; Andras Tigyi; Anna Ankirskaia; Imteaz Siddique; Helen Lam; Ed DePeters; Barry W. Wilson

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
214 KB
Volume
26
Category
Article
ISSN
1095-6670

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✦ Synopsis

Abstract

Pyridostigmine bromide (PB) has been used to protect soldiers from the toxic effects of soman, a chemical warfare agent. Recent research shows that pyridostigmine bromide protects a significant percentage of acetylcholinesterase in isolated human intercostal muscle. Findings presented here indicate that red blood cell acetylcholinesterase is similarly protected by pyridostigmine bromide from the action of diisopropyl fluorophosphate and several organophosphate pesticides including chlorpyrifos‐oxon, diazinon‐oxon, and paraoxon, but not malaoxon, using the bovine red blood cell as a subject. These findings suggest that pretreatment with PB may protect growers, farmworkers, first responders, and the public, in general, from the effects of selected pesticides. Β© 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:31–34, 2012; View this article online at wileyonlinelibrary.com. DOI 10:1002/jbt.20410

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