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Pyridopyrimidines. X. Synthesis of 3-Substituted 2-Thioxo-5,7-dimethylpyrido[2,3-d] pyrimidin-4(3H)-ones and their S-Alkylation Under Phase Transfer Conditions

✍ Scribed by Chaitanya G. Dave; Killol J. Patel

Book ID
102344370
Publisher
Journal of Heterocyclic Chemistry
Year
2001
Tongue
English
Weight
43 KB
Volume
38
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

2‐Thioxo‐5,7‐dimethylpyrido[2,3‐d]pyrimidin‐4(3__H__)‐ones 3 were synthesized by the cyclocondensation of 2‐amino‐3‐carbethoxy‐4,6‐dimethylpyridine 1 with methyl‐N‐aryldithiocarbamates 2 and compared with the condensation between 1 and aryl isothiocyanates 4. When a comparative study of N vs S alkylation of ambident 2‐thioxo‐5,7‐dimethylpyrido[2,3‐d]pyrimidin‐4(3__H__)‐ones 3 was carried out under liquid‐liquid and solid‐liquid phase transfer conditions using various alkylating agents 5, the S‐alkylated products 6 were obtained exclusively and selectively.

📜 SIMILAR VOLUMES

ChemInform Abstract: Pyridopyrimidines.
ChemInform Abstract: Pyridopyrimidines. Part 9. Synthesis and Antibacterial Activity of 2-Methylthio-6-phenylazo-5,7-dimethylpyrido[2,3-d]pyrimidin-4(3H)-ones.
✍ Chaitanya G. Dave; Manish C. Shukla 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Synthesis and S-methylation of 2-thioxop
Synthesis and S-methylation of 2-thioxopyrido[3′,2′:4,5]thieno[3,2-d]-pyrimidin-4(3H)-ones with and without a phase transfer catalyst
✍ Chaitanya G. Dave; A. B. Shah; H. C. Shah 📂 Article 📅 1997 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 250 KB

## Abstract A number of 2‐thioxopyrido[3′,2′:4,5]thieno[3,2‐__H__]pyrimdin‐4(3__H__‐ones (5) have been synthesized by cyclocondensation of 2‐carbethoxy‐3‐amino‐4‐phenyl‐6‐substituted‐thieno[2,3‐__b__]pyridines (3) with various isothiocyanates. Compounds 5 were __S__‐methylated routinely and the rea