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Synthesis and S-methylation of 2-thioxopyrido[3′,2′:4,5]thieno[3,2-d]-pyrimidin-4(3H)-ones with and without a phase transfer catalyst

✍ Scribed by Chaitanya G. Dave; A. B. Shah; H. C. Shah

Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
250 KB
Volume
34
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A number of 2‐thioxopyrido[3′,2′:4,5]thieno[3,2‐H]pyrimdin‐4(3__H__‐ones (5) have been synthesized by cyclocondensation of 2‐carbethoxy‐3‐amino‐4‐phenyl‐6‐substituted‐thieno[2,3‐b]pyridines (3) with various isothiocyanates. Compounds 5 were S‐methylated routinely and the reactions compared under solid‐liquid phase transfer conditions to obtain 2‐methylthiopyrido[3′,2′:4,5]thieno[3,2‐d]pyrimidin‐4(3__H__)‐^ones^ (6). The new triheterocyclic pyridothienopyrimidines were prepared with the objective to study their pharmacological properties.

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