Pyridazinoquinoxalines. V. Synthesis and study of the tuberculostatic activity of alkyl derivatives of dihydropyridazino[3,4-b]quinoxalines
✍ Scribed by G. S. Predvoditeleva; T. V. Kartseva; O. N. Oleshko; V. I. Shvedov; G. N. Pershin; T. N. Zykova; N. B. Lapaeva
- Book ID
- 112488294
- Publisher
- Springer
- Year
- 1977
- Tongue
- English
- Weight
- 372 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0091-150X
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## Abstract A new class of quinolones, 1,4‐dihydro‐4‐oxopyridazino[3,4‐__b__]quinoxaline‐3‐carboxylic acids and related compounds, were synthesized __via__ oxidation of 1,5‐dihydropyridazino[3,4‐__b__]quinoxalines obtained from 2‐hydrazinoquinoxaline 4‐oxides. Some of the 1,5‐dihydropyridazino[3,4‐
## Abstract The reaction of the 2‐(1‐alkylhydrazino)‐6‐chloroquinoxaline 4‐oxides **1a,b** with diethyl acetone‐dicarboxylate or 1,3‐cyclohexanedione gave ethyl 1‐alkyl‐7‐chloro‐3‐ethoxycarbonylmethylene‐1,5‐dihydropyridazino[3,4‐__b__]quinoxaline‐3‐carboxylates **5a,b** or 6‐alkyl‐10‐chloro‐1‐oxo‐
## Abstract The reaction of the alkylhydrazinoquinoxaline __N__‐oxides **2a‐d** with dimethyl acetylenedicarboxylate gave the dimethyl 1‐alkyl‐1,5‐dihydropyridazino[3,4‐__b__]qumoxaline‐3,4‐dicarboxylates **3a‐d**, whose reaction with nitrous acid effected the C~4~‐oxidation to afford the dimethyl