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Synthesis and biological activity of 1,5-dihydropyridazino-[3,4-b]quinoxalines and a new class of quinolones

✍ Scribed by Yoshihisa Kurasawa; Ho Sik Kim

Publisher
Journal of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
374 KB
Volume
35
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A new class of quinolones, 1,4‐dihydro‐4‐oxopyridazino[3,4‐b]quinoxaline‐3‐carboxylic acids and related compounds, were synthesized via oxidation of 1,5‐dihydropyridazino[3,4‐b]quinoxalines obtained from 2‐hydrazinoquinoxaline 4‐oxides. Some of the 1,5‐dihydropyridazino[3,4‐b]quinoxalines, 1,4‐dihydro‐4‐oxopyridazino[3,4‐b]quinoxaline‐3‐carboxylic acids, and related compounds showed biological activity.

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