Pyridazines 92. Synthesis of dialkyldipyridazinodiazepinones as potential HIV-1 reverse transcriptase inhibitors

✍ Scribed by Gottfried Heinisch; Barbara Matuszczak; Elisabeth Spielmann; Myriam Witvrouw; Christophe Pannecouque; Erik De Clercq

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2001
• Tongue: English
• Weight: 71 KB
• Volume: 38
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570380117

✦ Synopsis

Abstract

Two methods for the preparation of dialkylsubstituted dipyridazino[4,3‐b:3′,4′‐e][1,4]diazepinones and dipyridazino[3,4‐b:3′,4′‐e][1,4]diazepinones are reported. The new compounds were evaluated for their inhibitory effects against the replication of human immunodeficiency virus [HIV‐1(III~B~) and HIV‐2(ROD)] in MT‐4 cells.