Pyrethroid Decrease in Central Nervous System from Nerve Agent Pretreatment

✍ Scribed by Bruce A. Buchholz; Norma H. Pawley; John S. Vogel; Robert J. Mauthe

• Book ID: 101286666
• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 79 KB
• Volume: 17
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/(sici)1099-1263(199707)17:4<231::aid-jat434>3.0.co;2-j

✦ Synopsis

We studied the effect of pyridostigmine bromide, a nerve agent prophylactic, on the central nervous system (CNS) uptake of [ 14 C]permethrin, a pyrethroid insecticide, at scaled human-equivalent exposures in rats using accelerator mass spectrometry (AMS). AMS detects 14 C at attomole sensitivities and determines the tissue distribution of 14 C-labeled compounds. Pyridostigmine bromide in chow at 7.75 mg kg -1 per day lowered the CNS tissue levels of permethrin, dosed at 4.75 g kg -1 , in the CNS of rats by 30%. These results are inconsistent with hypothesized synergy of such compounds as a precursor to 'Gulf War syndrome'.