Pyrene End-Labeled Diblock Glycopolymers: Synthesis and Aggregation

✍ Scribed by Feng-Zhu Lu; Jian-Qiang Meng; Fu-Sheng Du; Zi-Chen Li; Bao-Yan Zhang

• Book ID: 102484969
• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 178 KB
• Volume: 206
• Category: Article
• ISSN: 1022-1352
• DOI: 10.1002/macp.200400354

✦ Synopsis

Abstract

Summary: A pyrene end‐labeled amphiphilic block copolymer, poly(ε‐caprolactone)‐block‐poly[6‐O‐(4‐vinylbenzyl)‐D‐galactose] (Py‐PCL‐b‐PVBG), was synthesized by a four‐step method. The aggregation behavior of the diblock copolymer in solution was studied by monitoring the fluorescence of pyrene. TEM measurements revealed that the aggregates obtained by first dissolving the copolymer in N,N‐dimethylformamide (DMF), followed by the addition of water, were primarily spheres with the PCL blocks in the core. The PVBG corona was then crosslinked with glutaraldehyde. Final removal of the PCL core was accomplished by degradation under basic conditions, which resulted in the formation of hollow glycopolymer nanospheres.

Structure of poly(ε‐caprolactone)‐block‐poly[6‐O‐(4‐vinylbenzyl)‐D‐galactose].

magnified imageStructure of poly(ε‐caprolactone)‐block‐poly[6‐O‐(4‐vinylbenzyl)‐D‐galactose].