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Pyrazoles and Pyrazolo[4,3-e]pyrrolo[1,2-a]pyrazines, I. Synthesis and Antimicrobial Activity

✍ Scribed by Abdel-Rahman Farghaly; Hussein El-Kashef


Publisher
Springer Vienna
Year
2004
Tongue
English
Weight
184 KB
Volume
136
Category
Article
ISSN
0026-9247

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Pyrazoles and pyrazolo[4,3-e]pyrrolo[1,2
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## Abstract Synthesis of the title compounds was achieved using the anils **2a**, **2b**, **2c**, **2d**, **2e** and **5a**, **5b**, **5c** derived from the 4‐aminopyrazole **1** as starting materials. These compounds were allowed to react with mercaptoacetic acid in boiling dry benzene to afford t

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The synthesis and properties of pyrrolo [1,2-a]pyrazines are reviewed. Some derivatives of pyrrolo[1,2-a]pyrazine possess neuroleptic, cardiovascular [1], and antidepressant [2] activity. Alkylated pyrrolo[1,2-a]pyrazines have been identified as ingredients of the smell of roasted meat [3]. Interest

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## Abstract The synthesis of the title compounds was achieved using the key intermediate ethyl 4,6‐dimethyl‐3‐(pyrrol‐1‐yl)thieno[2,3‐__b__]pyridine‐2‐ carboxylate 2. This latter compound was obtained __via__ the interaction of the thienopyridine amino ester 1 with 2,5 dimethoxytetrahydrofuran in a