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Pyrazofurin-resistant hepatoma cells deficient in adenosine kinase

✍ Scribed by D.Parker Suttle; Ronald J. Harkrader; Robert C. Jackson

Book ID
113146704
Publisher
Elsevier Science
Year
1981
Weight
690 KB
Volume
17
Category
Article
ISSN
0014-2964

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Purine excretion by mammalian cells defi
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## Abstract An adenosine kinaseless (AK^βˆ’^) mutant of the mouse fibroblast line 3T6 has been obtained in cell culture by evolution of resistance to 6‐thio‐methylpurine ribonucleoside and tubercidin. The mutant excretes purines (xanthine and hypoxanthine) into the culture medium. Human or mouse cell