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PX-478, a potent inhibitor of hypoxia-inducible factor-1 (HIF-1) and antitumor agent


Book ID
117659637
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
134 KB
Volume
38
Category
Article
ISSN
0959-8049

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PX-478, an inhibitor of hypoxia-inducibl
✍ Sanjeewani T. Palayoor; James B. Mitchell; David Cerna; William DeGraff; Molykut πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 French βš– 368 KB

## Abstract Overexpression of hypoxia‐inducible factor‐1Ξ± (HIF‐1Ξ±) in human tumors is associated with poor prognosis and poor outcome to radiation therapy. Inhibition of HIF‐1Ξ± is considered as a promising approach in cancer therapy. The purpose of this study was to test the efficacy of a novel HIF