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Putative DNA Quadruplex Formation within the Human c-kit Oncogene

✍ Scribed by Rankin, Sarah; Reszka, Anthony P.; Huppert, Julian; Zloh, Mire; Parkinson, Gary N.; Todd, Alan K.; Ladame, Sylvain; Balasubramanian, Shankar; Neidle, Stephen

Book ID
115452640
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
134 KB
Volume
127
Category
Article
ISSN
0002-7863

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Putative DNA Quadruplex Formation within
Putative DNA Quadruplex Formation within the Human c-kit Oncogene
✍ Rankin, Sarah; Reszka, Anthony P.; Huppert, Julian; Zloh, Mire; Parkinson, Gary πŸ“‚ Article πŸ“… 2005 πŸ› American Chemical Society 🌐 English βš– 134 KB

The DNA sequence, d(AGGGAGGGCGCTGGGAGGAGGG), occurs within the promoter region of the c-kit oncogene. We show here, using a combination of NMR, circular dichroism, and melting temperature measurements, that this sequence forms a four-stranded quadruplex structure under physiological conditions. Vari