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Purity determination as needed for the realisation of primary standards for elemental determination: status of international comparability

✍ Scribed by Heinrich Kipphardt; Ralf Matschat; Jochen Vogl; Tamara Gusarova; Michael Czerwensky; Hans-Joachim Heinrich; Akiharu Hioki; Leonid A. Konopelko; Brad Methven; Tsutomu Miura; Ole Petersen; Gundel Riebe; Ralph Sturgeon; Gregory C. Turk; Lee L. Yu


Book ID
106228841
Publisher
Springer-Verlag
Year
2009
Tongue
English
Weight
365 KB
Volume
15
Category
Article
ISSN
0949-1775

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## Abstract A simple, reliable and sensitive liquid chromatography tandem mass spectrometry (LC‐MS/MS) protocol was developed and validated for quantification of bisoprolol in human plasma. The sample was pretreated with a simple procedure of protein precipitation and an isotope‐labeled d5‐bisoprol