✦ LIBER ✦

Purinoceptors in the regulation of cell growth and differentiation

✍ Scribed by Joseph T. Neary; Geoffrey Burnstock

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 641 KB
Volume: 39
Category: Article
ISSN: 0272-4391
DOI: 10.1002/(sici)1098-2299(199611/12)39:3/4<407::aid-ddr22>3.0.co;2-x

No coin nor oath required. For personal study only.

✦ Synopsis

Tropic actions of extracellular nucleotides and nucleosides have been described in both the central and peripheral nervous systems as well as for numerous other cell types. These effects on cellular differentiation and proliferation are mediated by specific cell surface PI and P2 receptors. In some cases, extracellular purines act synergistically with polypeptide growth factors. The signal-transduction pathways that couple the PI or P2 receptors to changes in cell growth are beginning to be uncovered. The trophic actions of purines have both physiological and pathological implications and may play important roles in development and synaptogenesis as well as in tissue injury and repair.

📜 SIMILAR VOLUMES

Differential signalling of purinoceptors

Differential signalling of purinoceptors in HeLa cells through the extracellular signal-regulated kinase and protein kinase C pathways

✍ Antonella Muscella; Simona Greco; Maria Giovanna Elia; Carlo Storelli; Santo Mar 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 377 KB 👁 1 views

## Abstract We have previously shown that HeLa cells express P2Y~2~ and P2Y~6~ receptors endogenously and determined the pathways by which the P2Y~2~ controls proliferation and Na^+^/K^+^ATPase activity. Our objective in this study was to investigate the hypothesis that P2Y~6~ also controls prolife

Butterfat fatty acids differentially reg

Butterfat fatty acids differentially regulate growth and differentiation in Jurkat T-cells

✍ Paolo Bergamo; Diomira Luongo; Francesco Maurano; Mauro Rossi 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 234 KB

## Abstract Synthetic Conjugated Linoleic Acid mixture (CLA; c9,t11; t10,c12‐18:2) has been previously shown to inhibit growth, and enhance apoptosis and IL‐2 mRNA synthesis in human lymphoblastic Jurkat T‐cells. In this study, two different butterfat types were evaluated and compared for their eff

Regulation of mast cell differentiation

✍ Yukihiko Kitamura; Jun Fujita 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 556 KB

Regulation of B cell growth and differen

Regulation of B cell growth and differentiation via CD21 and CD40

✍ Karol Axcrona; David Gray; Tomas Leanderson 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 465 KB

Stimulation in vitro of murine splenic B cells by lipopolysaccharide, anti-x Sepharose, anti-CD40 or allo-reactive T helper cells all up-regulated CD21 and CD23 surface expression. Neither anti-CD21 nor anti-CD23 antibodies induced B cell growth or differentiation when added in soluble form or coupl

Regulation of murine B cell growth and d

Regulation of murine B cell growth and differentiation by CD30 ligand

✍ Kurt D. Shanebeck; Charles R. Maliszewski; Mary K. Kennedy; Kathleen S. Picha; C 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 759 KB

Differential regulation of platelet-deri

Differential regulation of platelet-derived growth factor stimulated migration and proliferation in osteoblastic cells

✍ Meenal Mehrotra; Stephen M. Krane; Kristen Walters; Carol Pilbeam 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 343 KB 👁 1 views

## Abstract Osteoblastic migration and proliferation in response to growth factors are essential for skeletal development, bone remodeling, and fracture repair, as well as pathologic processes, such as metastasis. We studied migration in response to platelet‐derived growth factor (PDGF, 10 ng/ml) i