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Purinergic P2 receptors as targets for novel analgesics

โœ Scribed by Geoffrey Burnstock


Book ID
113845689
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
801 KB
Volume
110
Category
Article
ISSN
0163-7258

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โœ S. Jeffrey Dixon; Stephen M. Sims ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 268 KB

Extracellular nucleotides like ATP bind to cell surface receptors (P2 purinergic receptors) in many tissues. P2X receptor subtypes are intrinsic ion channels that mediate depolarization and influx of Ca 2+ , whereas the P2Y receptor subtypes couple through G proteins to activation of phospholipase C