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P2Y purinergic receptors: New targets for analgesic and antimigraine drugs

โœ Scribed by Magni, Giulia; Ceruti, Stefania


Book ID
120154157
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
733 KB
Volume
85
Category
Article
ISSN
0006-2952

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Extracellular nucleotides like ATP bind to cell surface receptors (P2 purinergic receptors) in many tissues. P2X receptor subtypes are intrinsic ion channels that mediate depolarization and influx of Ca 2+ , whereas the P2Y receptor subtypes couple through G proteins to activation of phospholipase C