Purine n-oxides XXIV. The preparation of 8-substituted xanthines and guanines by a nucleophilic displacement of a 3-substituent

✍ Scribed by Uwe Wölcke; Nigel J.M. Birdsall; George Bosworth Brown

• Book ID: 104239136
• Publisher: Elsevier Science
• Year: 1969
• Tongue: French
• Weight: 188 KB
• Volume: 10
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)87809-6

✦ Synopsis

In a recent publication (2) on the rearrangement of purine j-N-oxides to 8-hydroxypurines in acid anhydrides, a postulated intermediate was the 0-acyl derivative of the N-oxide. Such an intermediate, 3-acetoxyxanthine (II), [ctx5 267 mp (E 14,000)], has now been prepared by