Purification of123I and124I for antibody labelling
β Scribed by R. M. Lambrecht
- Book ID
- 112707564
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 371 KB
- Volume
- 146
- Category
- Article
- ISSN
- 1588-2780
No coin nor oath required. For personal study only.
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The radiochemical syntheses of methyl 2-[123I]-iodoisonicotinate, 2-[123I]-iodoisonicotinic acid hydrazide and 2-[124I]-iodoisonicotinic acid hydrazide was accomplished. Iodine-123 was incorporated in the methyl ester molecule by an exchange reaction in glacial acetic acid. The average efficiency of
## Abstract This study describes the radioiodination of an antibody specific to the vascular endothelial growth factor (VEGF), VG76e, with [^124^I]iodine to obtain a novel PET tracer for measurement of angiogenesis. __In vitro__ binding assays showed a significantly higher immunoreactive fraction w