𝔖 Bobbio Scriptorium
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Purification of123I and124I for antibody labelling

✍ Scribed by R. M. Lambrecht


Book ID
112707564
Publisher
Springer
Year
1990
Tongue
English
Weight
371 KB
Volume
146
Category
Article
ISSN
1588-2780

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The radiochemical syntheses of methyl 2-[123I]-iodoisonicotinate, 2-[123I]-iodoisonicotinic acid hydrazide and 2-[124I]-iodoisonicotinic acid hydrazide was accomplished. Iodine-123 was incorporated in the methyl ester molecule by an exchange reaction in glacial acetic acid. The average efficiency of

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## Abstract This study describes the radioiodination of an antibody specific to the vascular endothelial growth factor (VEGF), VG76e, with [^124^I]iodine to obtain a novel PET tracer for measurement of angiogenesis. __In vitro__ binding assays showed a significantly higher immunoreactive fraction w