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Purification and stabilization of a poorly soluble mouse IgG3 monoclonal antibody

✍ Scribed by Wim Jiskoot; Anna-Myra V. Hoven; Ada A.M. De Koning; Mia F. Leerling; C.H.Karin Reubsaet; Daan J.A. Crommelin; E.Coen Beuvery


Book ID
118902267
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
555 KB
Volume
138
Category
Article
ISSN
0022-1759

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Tungsten microparticles may be introduced into some pre-filled syringes during the creation of the needle hole. In turn, these microcontaminants may interact with protein therapeutics to produce visible particles. We found that soluble tungsten polyanions formed in acidic buffer below pH 6.0 can pre