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Biological Activity of Human--Mouse IgG1, IgG2, IgG3, and IgG4 Chimeric Monoclonal Antibodies with Antitumor Specificity

✍ Scribed by Zenon Steplewski, Lee K. Sun, Clyde W. Shearman, John Ghrayeb, Peter Daddona and Hilary Koprowski

Book ID
123635712
Publisher
National Academy of Sciences
Year
1988
Tongue
English
Weight
893 KB
Volume
85
Category
Article
ISSN
0027-8424

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C1q binding to chimeric monoclonal IgG3
C1q binding to chimeric monoclonal IgG3 antibodies consisting of mouse variable regions and human constant regions with shortened hinge containing 15 to 47 amino acids
✍ Inger Sandlie; Audun Aase; Christina Westby; Terje E. Michaelsen πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 708 KB

Materials and methods ### 2.1 Immunological reagents and buffers Anti-C1 q was supplied by Dako (Copenhagen, Denmark). All other antibodies and conjugates were made in our laboratory. Isotonic Verona1 buffer of pH 7.3 was prepared with 1 mM MgCI2 and 1 mM CaCI2.