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Purification and characterization of tissue plasminogen activator kringle-2 domain expressed in Escherichia coli

✍ Scribed by Cleary, Scott; Mulkerrin, Michael G.; Kelley, Robert F.


Book ID
118019961
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
975 KB
Volume
28
Category
Article
ISSN
0006-2960

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Thermodynamics of ligand binding and den
✍ Robert F. Kelley; Abraham M. DeVos; Scott Cleary πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 975 KB

## Abstract The contribution of His64 to the function and stability of tissue plasminogen activator (t‐PA) kringle‐2 domain (His244 in t‐PA numbering) has been studied by using microcalorimetric methods to compare the ligand binding and thermal denaturation behavior of wild‐type kringle‐2 and mutan