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Purification and Characterization of the Catalytic Domain of Protein Tyrosine Phosphatase SHP-1 and the Preparation of Anti-ΔSHP-1 Antibodies

✍ Scribed by LI, W; ZHUANG, Y; LI, H; SUN, Y; FU, Y; WU, X; ZHAO, Z; FU, X

Book ID: 122818612
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 532 KB
Volume: 24
Category: Article
ISSN: 1005-9040
DOI: 10.1016/S1005-9040(08)60125-7

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## Abstract The conserved WPD loop of protein tyrosine phosphatases play an important role in the catalytic activity and the invariant aspartate residue acts as a general acid/base catalyst in the dephosphorylation reaction. In our previous report, we have demonstrated that the catalytic activities