Expression, Purification, and Crystallization of the Catalytic Domain of Protein Tyrosine Phosphatase SHP-1
โ Scribed by Xiaoshan Liang; Wuyi Meng; Tianqi Niu; Zhizhuang Zhao; G.Wayne Zhou
- Book ID
- 115633872
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 61 KB
- Volume
- 120
- Category
- Article
- ISSN
- 1047-8477
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Previous studies in this laboratory have shown that the SH-2 domaincontaining protein tyrosine phosphatase SHP-1 is expressed in CNS glia and functions to modulate cytokine activities in these cells. The present study demonstrates that SHP-1 is expressed within multiple regions of the CNS in vivo, e
## Abstract The conserved WPD loop of protein tyrosine phosphatases play an important role in the catalytic activity and the invariant aspartate residue acts as a general acid/base catalyst in the dephosphorylation reaction. In our previous report, we have demonstrated that the catalytic activities