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Purification and Characterization of NF-R2 that Regulates the Expression of the Human Multidrug Resistance (MDR1) Gene

✍ Scribed by Takatori, Toshiro ;Ogura, Mitsuo ;Tsuruo, Takashi


Book ID
108580771
Publisher
Wiley (Blackwell Publishing)
Year
1993
Tongue
English
Weight
386 KB
Volume
84
Category
Article
ISSN
0910-5050

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The human multidrug resistance protein 2 (MRP2), also termed as the canalicular multispecific organic anion transporter (cMOAT), is a member of the adenosine triphosphatebinding cassette transporter superfamily. In the liver, MRP2 mediates the multispecific efflux of various types of organic anions,

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## Abstract ## BACKGROUND The P‐glyprotein (P‐gp), which is a membrane channel encoded by the __MDR1__ gene, represents a possible explanation for multidrug resistance in human hepatoblastoma (HB). P‐gp shows up‐regulation in tumor cells after chemotherapy; however, to date, its exact role in HB h