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Clinical scale production of an improved retroviral vector expressing the human multidrug resistance 1 gene (MDR1)

✍ Scribed by Eckert, H-G; Kühlcke, K; Schilz, A J; Lindemann, C; Basara, N; Fauser, A A; Baum, C

Book ID
110012545
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
67 KB
Volume
25
Category
Article
ISSN
0007-1188

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## Abstract ## BACKGROUND The P‐glyprotein (P‐gp), which is a membrane channel encoded by the __MDR1__ gene, represents a possible explanation for multidrug resistance in human hepatoblastoma (HB). P‐gp shows up‐regulation in tumor cells after chemotherapy; however, to date, its exact role in HB h