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Pure akinesia due to lewy body Parkinson's disease: A case with pathology

✍ Scribed by N. P. Quinn; P. Luthert; M. Honavar; C. D. Marsden

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 390 KB
Volume: 4
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.870040112

No coin nor oath required. For personal study only.

✦ Synopsis

The case of a patient with levodopa-responsive pure akinesia and freezing of gait for 17 years, whose brain showed the classical changes of Lewy body Parkinson's disease at postmortem is presented. A short trial of DLthreo-DOPS was ineffective. Intellectual function was preserved despite the presence of Lewy bodies and mild cell loss in subcortical cholinergic nuclei. Pure akinesia is likely to be a heterogeneous condition, with most cases having little or no response to levodopa therapy. However, this case demonstrates that this clinical picture may be caused by Lewy body Parkinson's disease.

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