Pummerer reaction methodology for the synthesis of 5-thiophenyl substituted oxazoles

✍ Scribed by Jennifer D Kreisberg; Philip Magnus; Shirin Shinde

• Book ID: 104251980
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 230 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01704-5

✦ Synopsis

Treatment of N-acylamino-2-thiophenyl derivatives with N-chlorosuccinimide (2.0 equiv.) followed by SnCl 4 (0.1-1.0 equiv.) provides a direct synthesis of 5-thiophenyloxazoles.