Pulsed high-dose dexamethasone treatment of polyneuropathy associated with monoclonal gammopathy
β Scribed by N. C. Notermans; M. Vermeulen; H. M. Lokhorst; P. A. Van Doorn; L. H. Van den Berg; L. L. Teunissen; J. H. J. Wokke
- Book ID
- 106095589
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 18 KB
- Volume
- 244
- Category
- Article
- ISSN
- 0340-5354
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A number of common disorders of the peripheral nervous system are closely linked to a monoclonal gammopathy. In a minority of patients, the neuropathy represents the sentinel feature of a malignant plasma cell dyscrasia, such as multiple myeloma or its osteosclerotic variant, Waldenstrom's disease,
Fourteen patients with HTLV-1-associated myelopathy were treated with high-dose intravenous gammaglobulin (IVGG). Ten received 10 g/day of IVGG and 4 received 400 mg/kg of body-weight/day of IVGG for 5 consecutive days. Improvement of spastic paraparesis was observed in 10 within 7 days of the comme