✦ LIBER ✦

Treatment of HTLV-I-associated myelopathy with high-dose intravenous gammaglobulin

✍ Scribed by Y. Kuroda; H. Takashima; A. Ikeda; C. Endo; R. Neshige; R. Kakigi; H. Shibasaki

Book ID: 104719120
Publisher: Springer
Year: 1991
Tongue: English
Weight: 525 KB
Volume: 238
Category: Article
ISSN: 0340-5354
DOI: 10.1007/bf00315327

No coin nor oath required. For personal study only.

✦ Synopsis

Fourteen patients with HTLV-1-associated myelopathy were treated with high-dose intravenous gammaglobulin (IVGG). Ten received 10 g/day of IVGG and 4 received 400 mg/kg of body-weight/day of IVGG for 5 consecutive days. Improvement of spastic paraparesis was observed in 10 within 7 days of the commencement of IVGG. The therapeutic effects were sustained for more than 3 weeks in some patients. There were no side effects. Analysis of factors of relevance to the clinical improvement with IVGG showed that the beneficial response was preferentially found in patients having a high CSF titre of anti-HTLV-I antibodies, a high CSF IgG level and a marked brain MRI abnormality.

📜 SIMILAR VOLUMES

Nationwide survey of HTLV-I–associated m

Nationwide survey of HTLV-I–associated myelopathy in Japan: Association with blood transfusion

✍ Dr Mitsuhiro Osame; Robert Janssen; Hiroaki Kubota; Hiroshi Nishitani; Akihiro I 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 657 KB

Immunohistochemical characteristics of p

Immunohistochemical characteristics of polymyositis in patients with HTLV-1–associated myelopathy and HTLV-I carriers

✍ Dr. Itsuro Higuchi; Dr. Elizabeth S. Montemayor; Dr. Syuji Izumo; Dr. Masaru Ino 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 502 KB

Durable remission of pure red cell aplas

Durable remission of pure red cell aplasia after treatment with high-dose intravenous gammaglobulin and prednisone

✍ Dr. Samuel W. Needleman 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 235 KB 👁 2 views

Pregnancy-associated factor VIII inhibit

Pregnancy-associated factor VIII inhibitor: Treatment with intravenous high-dose immunoglobulin

✍ Christine D. Hudak; C. Harris Spiridonidis; Albert J. Hart; Steven A. Betras; Le 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB 👁 2 views

HLA haplotype-linked high immune respons

HLA haplotype-linked high immune responsiveness against HTLV-I in HTLV-I-associated myelopathy: Comparison with adult T-cell leukemia/lymphoma

✍ Koichiro Usuku; Dr. Shunro Sonoda; Mitsuhiro Osame; Shinji Yashiki; Kazuo Takaha 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 729 KB

Sequence heterogeneity of HTLV-I provira

Sequence heterogeneity of HTLV-I proviral DNA in the central nervous system of patients with HTLV-I–associated myelopathy

✍ Dr. Jun-ichi Kira; Yoshio Koyanagi; Takeshi Yamada; Yasuto Itoyama; Jun Tateishi 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 774 KB

The nucleotide sequence of human T-lymphotropic virus type I (HTLV-I) in central nervous system tissue was determined in 3 autopsy cases with HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) and 1 seropositive carrier without HAM/TSP but with multiple sclerosis. All HAM/TSP samp