𝔖 Bobbio Scriptorium
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Pulse cyclophosphamide therapy for wegener's granulomatosis

✍ Scribed by John S. Cowdery

Book ID
115683474
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
275 KB
Volume
91
Category
Article
ISSN
1555-7162

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## Summary The introduction of cyclophosphamide (CyP) as a treatment for Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) has been among the most significant contributions in vasculitis. Prior to the introduction of CyP, WG was a uniformly fatal disease, with mortality occurring wit

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## Abstract ## Objective Standard treatment for severe granulomatosis with polyangiitis (Wegener's) (GPA) is daily oral cyclophosphamide (CYC), a cytotoxic agent associated with ovarian failure. In this study, we assessed the rate of diminished ovarian reserve in women with GPA who received CYC ve