Pulsatile GnRH regulation of gonadotropin subunit gene transcription
β Scribed by Margaret A. Shupnik; Patricia C. Fallest
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 260 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0149-7634
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Gonadotropin-releasing hormone (GnRH) stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from pituitary gonadotrope cells. Additional receptor-mediated actions of the releasing hormone include homologous regulation of both the GnRH receptor and of cell responsiveness.
The transcriptional regulation of MHC class II genes involves the interaction of DNA-binding proteins with specific DNA sequences. The cis elements of the promoter region have now been well delineated functionally, while the proteins that interact with these elements are just beginning to be identif