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Regulation of gonadotropin release, GnRH receptors, and gonadotrope responsiveness: A role for GnRH receptor microaggregation

โœ Scribed by P. Michael Conn; Deloris C. Rogers; Sallie G. Seay; Hyder Jinnah; Michael Bates; Diana Luscher

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
584 KB
Volume
27
Category
Article
ISSN
0730-2312

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โœฆ Synopsis

Gonadotropin-releasing hormone (GnRH) stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from pituitary gonadotrope cells. Additional receptor-mediated actions of the releasing hormone include homologous regulation of both the GnRH receptor and of cell responsiveness. While it is apparent that the release mechanism is Ca2+ mediated, it remains unclear how this receptormediated action is integrated with regulation of the receptor and with cell responsiveness. It is the purpose of this review to describe the requirements for gonadotropin release as well as for receptor and response regulation in order to prepare an integrated model for these actions of the releasing hormone.

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โœ Maria Keramida; John M. Matsoukas; Dimitris Panagiotopoulos; Kostas Alexopoulos; ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Springer Netherlands ๐ŸŒ English โš– 344 KB

Gonadotropin-releasing hormone (GnRH) stimulates the release and synthesis of gonadotropin hormones (GtH) and is the key regulator of reproduction. The present study was carried out to design a potent GnRH analogue containing Tyr(OMe) at position 5 and a D-amino acid at position 6. This was based on