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Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity

✍ Scribed by Akira Iyoda; Kenzo Hiroshima; Yasumitsu Moriya; Teruaki Mizobuchi; Mizuto Otsuji; Yasuo Sekine; Kiyoshi Shibuya; Toshihiko Iizasa; Yukio Saitoh; Takehiko Fujisawa

Book ID: 117981490
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 517 KB
Volume: 77
Category: Article
ISSN: 0003-4975
DOI: 10.1016/j.athoracsur.2003.10.119

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## Abstract ## BACKGROUND Small cell lung carcinoma (SCLC) and pulmonary large cell neuroendocrine carcinoma (LCNEC) are high‐grade malignant neuroendocrine tumors. Histologic differentiation between SCLC and LCNEC is difficult in some cases and to the authors' knowledge, genetic alterations assoc