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Complexity in the treatment of pulmonary large cell neuroendocrine carcinoma

✍ Scribed by Toshiyuki Kozuki; Nobukazu Fujimoto; Hiroshi Ueoka; Katsuyuki Kiura; Keiichi Fujiwara; Katsuhiko Shiomi; Koichi Mizobuchi; Masahiro Tabata; Shuji Hamazaki; Mitsune Tanimoto


Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
191 KB
Volume
131
Category
Article
ISSN
1432-1335

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## Abstract ## BACKGROUND Small cell lung carcinoma (SCLC) and pulmonary large cell neuroendocrine carcinoma (LCNEC) are high‐grade malignant neuroendocrine tumors. Histologic differentiation between SCLC and LCNEC is difficult in some cases and to the authors' knowledge, genetic alterations assoc

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## BACKGROUND. Large cell neuroendocrine carcinoma (LCNEC) of the lung has been proposed as a new disease entity. To establish diagnostic features, bronchial brush cytologic findings were evaluated. ## METHODS. Bronchial brush cytology material of 20 LCNECs was evaluated by light microscopy and