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Pulmonary Hypertension of Sickle Cell Disease Beyond Classification Constraints

โœ Scribed by Klings, Elizabeth S.; Morris, Claudia R.; Hsu, Lewis L.; Castro, Oswaldo; Gladwin, Mark T.; Mubarak, Kamal K.

Book ID
122217048
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
62 KB
Volume
63
Category
Article
ISSN
1558-3597

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In patients with sickle cell disease, anemia is a recognized risk factor for stroke, death, and the development of pulmonary hypertension. We have proposed that hemolytic anemia results in endothelial dysfunction and vascular instability and can ultimately lead to a proliferative vasculopathy leadin