Pulmonary hypertension and thalidomide therapy in multiple myeloma
✍ Scribed by Hattori, Yutaka ;Shimoda, Masayuki ;Okamoto, Shinichiro ;Satoh, Toru ;Kakimoto, Tsunayuki ;Ikeda, Yasuo
- Book ID
- 108673079
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 389 KB
- Volume
- 128
- Category
- Article
- ISSN
- 0007-1048
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Thalidomide was first evaluated in patients with refractory multiple myeloma in the mid-90s. Based on the promising results achieved in these patients, the drug was subsequently used in earlier stages of the disease. Meanwhile, numerous phase II studies have been published using different doses and
## Abstract The value of thalidomide–dexamethasone was assessed in 26 consecutive, previously untreated patients with multiple myeloma of high tumor mass. All showed Hgb < 8.5 g/dL, serum calcium > 11.5 mg/dL, or both. The response rate was 73%, frequency of early death < 3 months was 5%, projected