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Pulmonary hemorrhage and glomerulonephritis in primary biliary cirrhosis

✍ Scribed by François Bissuel; Thierry Bizollon; Frédérique Dijoud; Paul Bouletreau; Jean François Cordier; Charles Chazot; Christian Gouillat; Christian Trepo

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 565 KB
Volume: 16
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840160609

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✦ Synopsis

W e obeerved life-threatening intrapulmonary hemorrhages and focal proliferative glomerulonephritis in a 41-yr-old woman with primary biliary cirrhosis. The severity of the symptoms necessitated blood transfusions and mechanical ventilation; the patient improved with the help of corticosteroid therapy. No formal evidence of either Goodpasture's syndrome or any other well-defined systemic vasculitis could be found. Neutrophil cytoplasmic antibodies were initially poeitive and became undetectable after 3 mo of immunomppmssive treatment without relapse. This association has not been described previously and may be added to the list of extrahepatic immune-mediated conditions associated with primary biliary cirrhosis.

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