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PTP1B Suppresses Prolactin Activation of Stat5 in Breast Cancer Cells

✍ Scribed by Kevin J. Johnson; Amy R. Peck; Chengbao Liu; Thai H. Tran; Fransiscus E. Utama; Ashley B. Sjolund; John D. Schaber; Agnieszka K. Witkiewicz; Hallgeir Rui


Book ID
117971040
Publisher
American Society for Investigative Pathology
Year
2010
Tongue
English
Weight
974 KB
Volume
177
Category
Article
ISSN
0002-9440

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## Abstract Profilin‐1 (Pfn1), a ubiquitously expressed actin‐binding protein, has been regarded as a tumor‐suppressor molecule for breast cancer. Since AKT signaling impacts cell survival and proliferation, in this study we investigated whether AKT activation in breast cancer cells is sensitive to