Pteridines. XXXIV. Synthesis of 8-hydroxy-7(8H)-pteridinones (pteridine hydroxamic acids)
β Scribed by Taylor, Edward C.; Jacobi, Peter A.
- Book ID
- 127085429
- Publisher
- American Chemical Society
- Year
- 1975
- Tongue
- English
- Weight
- 630 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
## Abstract The reactions of 5,6βdiaminopyrimidinβ4(3__H__)βone derivatives 1aβh, with dimethyl acetylenedicarboxylate are discussed in this paper. 6βAminoβ5β(__E__)(1β²,2β²βdicarbomethoxyvinyl)aminopyrimidines, 2, and 6β(methylenecarbomethoxy)pteridinones, 3, have been obtained as main the products,
The first representative of the &substituted 4-thiolumazine series has been synthesized. In a sequence of reactions, 4,6-dichloropyrimidin-2-( 1 H)-one (1) is first converted into 4-chloro-6-(methylamino)pyrimidin-2( 1H)one (6), then the Cl-atom displaced by the thioxo group ( +7) followed by a coup