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Synthesis and antiviral evaluation of several 6-(Methylene-carbomethoxy)pteridine-4,7(3H,8H)-diones

✍ Scribed by S. Molina; J. Cobo; A. Sánchez; M. Nogueras; E. De Clercq

Book ID: 102341301
Publisher: Journal of Heterocyclic Chemistry
Year: 1999
Tongue: English
Weight: 409 KB
Volume: 36
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570360216

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✦ Synopsis

Abstract

The reactions of 5,6‐diaminopyrimidin‐4(3__H__)‐one derivatives 1a‐h, with dimethyl acetylenedicarboxylate are discussed in this paper. 6‐Amino‐5‐(E)(1′,2′‐dicarbomethoxyvinyl)aminopyrimidines, 2, and 6‐(methylenecarbomethoxy)pteridinones, 3, have been obtained as main the products, which can be explained on the basis of a Michael addition on pyrimidine derivatives, and cyclization. Those compounds were evaluated for their in vitro antiviral activity.

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